Release and intestinal translocation of chemicals associated with microplastics in an in vitro human gastrointestinal digestion model

Peters, Ruud; de Jong, Nadine; de Haan, Laura; Wright, Stephanie; Bouwmeester, Hans

doi:10.1186/s43591-021-00022-y

Microplastics and Nanoplastics

Table 4 Overview of all identified metals and in which microplastics sample they were detected

From: Release and intestinal translocation of chemicals associated with microplastics in an in vitro human gastrointestinal digestion model

Name	CAS nr	Present in sample	chronic oral PoD (mg/kg day)	Point of Departure	Species
Li 7	7439-93-2	ENV-1, ENV-3, PA, PE, PET, PP-1, PP-2, PVC	1.2	NOAEL	human
Ti 47	7440-32-6	ENV-1, ENV-3, PA, PE, PP-1, PP-2, PS, PVC	24,000	NOEL	rat
V 51	7440-62-2	ENV-1, ENV-3, PA, PE, PP-1, PVC	0.22	NOAEL	rat
Cr 52	7440-47-3	ENV-1, ENV-3, PA, PE, PVC	1216	NOAEL	rat
Mn 55	7439-96-5	ENV-1, ENV-3, PA, PE, PET, PP-1, PP-2, PS,PVC	0.14	NOAEL	human
Fe 56	7429-89-6	ENV-1, ENV-3, PA, PE, PP-1	1	LOAEL	human
Co 59	7440-48-4	ENV-1, ENV-3, PA, PE, PET	1	LOAEL	human
Ni 60	7440–02-0	ENV-1, ENV-3	5	NOAEL	rat
Cu 65	7440-50-8	ENV-1, ENV-3, PA, PE,PS	5.3	LOAEL	human
Zn 66	7440-66-6	ENV-1, ENV-3, PVC	0.9	NOAEL	human
As 75	7440-38-2	ENV-1, ENV-3, PVC	0.0009	NOAEL	human
Se 78	7782-49-2	ENV-1, ENV-3	0.015	NOAEL	human
Rb 85	7440-17-7	ENV-1, ENV-3, PVC	5.3	LOAEL	not mentioned
Sr 88	7440-24-6	ENV-1, ENV-3, PA, PE, PP-1, PVC	60	NOAEL	human
Zr 91	7440-67-7	ENV-1, ENV-3, PA, PE, PET, PP-1, PP-2, PVC	3156	NOAEL	rat
Mo 98	7439-98-7	ENV-1, ENV-3, PA, PE, PP-1, PVC	5	NOAEL	human
Ag 107	7440-22-4	ENV-1, ENV-3, PA, PE, PVC	0.014	LOAEL	not mentioned
Cd 111	7440-43-9	ENV-1, ENV-3	0.0003	NOAEL	human
Sn 118	7440-31-5	ENV-1, ENV-3, PE, PET, PS, PVC	30	NOAEL (subacute)	human
Sb 121	7440-36-0	ENV-1, ENV-3, PE, PET, PP-1	0.06	NOAEL (subacute)	human
Ba 138	7440-39-3	ENV-1, ENV-3, PA, PE, PP-1	0.21	NOAEL	human
Ce 140	7440-46-2	ENV-1, ENV-3, PA, PP-1, PVC	n.d.	n.d.	n.d.
Ta 181	7440-25-7	ENV-1, PA, PET, PS	n.d.	n.d.	n.d.
W 184	7440-33-7	ENV-1, PA, PE	2	NOAEL	rat
Re 187	7440-15-5	ENV-1, PP-1	n.d.	n.d.	n.d.
Tl 205	7440-28-0	ENV-1, ENV-3, PA, PET,PP-1	0.04	NOAEL	not mentioned
Pb 208	7439-92-1	ENV-1, ENV-3, PA, PE,PP-1, PS, PVC	0.5	BMDL01	human
Bi 209	7440-69-9	ENV-1, ENV-3, PA, PE,PP-2, PS	25	NOAEL	rat

For each metal it is indicated if a point of departure (PoD) was listed in the TOXCAST database. ENV-1 environmental microplastic < 1 mm, environmental microplastic < 3 mm, PA polyamide, PE Polyethylene, PET Polyethylene terephthalate, PP-1/PP-2 Polypropylene, PS Polystyrene, PVC Polyvinylchloride

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