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Table 4 Sensitivity analysis of screening level (μg·L−1) for the most sensitive POD identified as a reduction in AMH concentration as shown in Table 3 and Fig. 4

From: Development and application of a health-based framework for informing regulatory action in relation to exposure of microplastic particles in California drinking water

Reference dosea = 0.024 mg·kg−1·d−1 (BMDL)
  RSC = 0.00001 RSC = 0.20 RSC = 0.50
DWI = 0.022 L·kg−1·d−1 0.011 230 540
DWI = 0.053 L·kg−1·d−1 0.0045 90 240
DWI = 0.135 L·kg−1·d−1 0.0018 36 89
Reference dosea = 0.034 mg·kg−1·d−1 (BMD)
  RSC = 0.00001 RSC = 0.20 RSC = 0.50
DWI = 0.022 L·kg−1·d−1 0.015 310 760
DWI = 0.053 L·kg−1·d−1 0.0063 130 320
DWI = 0.135 L·kg−1·d−1 0.0025 50 120
Reference dosea 0.141 mg·kg−1·d−1 (BMDU)
  RSC = 0.00001 RSC = 0.20 RSC = 0.50
DWI = 0.022 L·kg−1·d−1 0.064 1300 3200
DWI = 0.053 L·kg−1·d−1 0.027 530 1300
DWI = 0.135 L·kg−1·d−1 0.010 210 520
  1. aA composite uncertainty factor of 1 was used for derivation of these reference doses. The default composite UF that OEHHA would use in this case would be 300