Microplastics and Nanoplastics

Table 4 Sensitivity analysis of screening level (μg·L⁻¹) for the most sensitive POD identified as a reduction in AMH concentration as shown in Table 3 and Fig. 4

From: Development and application of a health-based framework for informing regulatory action in relation to exposure of microplastic particles in California drinking water

Reference dose^a = 0.024 mg·kg⁻¹·d⁻¹ (BMDL)
	RSC = 0.00001	RSC = 0.20	RSC = 0.50
DWI = 0.022 L·kg⁻¹·d⁻¹	0.011	230	540
DWI = 0.053 L·kg⁻¹·d⁻¹	0.0045	90	240
DWI = 0.135 L·kg⁻¹·d⁻¹	0.0018	36	89
Reference dose^a = 0.034 mg·kg⁻¹·d⁻¹ (BMD)
	RSC = 0.00001	RSC = 0.20	RSC = 0.50
DWI = 0.022 L·kg⁻¹·d⁻¹	0.015	310	760
DWI = 0.053 L·kg⁻¹·d⁻¹	0.0063	130	320
DWI = 0.135 L·kg⁻¹·d⁻¹	0.0025	50	120
Reference dose^a 0.141 mg·kg⁻¹·d⁻¹ (BMDU)
	RSC = 0.00001	RSC = 0.20	RSC = 0.50
DWI = 0.022 L·kg⁻¹·d⁻¹	0.064	1300	3200
DWI = 0.053 L·kg⁻¹·d⁻¹	0.027	530	1300
DWI = 0.135 L·kg⁻¹·d⁻¹	0.010	210	520

^aA composite uncertainty factor of 1 was used for derivation of these reference doses. The default composite UF that OEHHA would use in this case would be 300

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